TOXICOLOGICAL PROFILE OF METHANOL LEAF EXTRACT OF Annogeissus leiocarpus (DC.) GILL AND PEER IN ALBINO WISTER RATS
INNALEGWU, D. A., AMUDA, O., GARA, T. Y. AND MUHAMMAD, F. M.
ABSTRACT
Toxicity of medicinal plants and dose quantification is one of the major challenges confronting its acceptance and usage. This research is aimed at evaluating the toxicological profile of methanol leaf extract of Annogeissus leiocarpus in Albino Wister Rats. Acute and sub-chronic toxicity of the extract was carried out using the methods described by Lorke’s and Organization for Economic Co-operation and
Development respectively. Histopathology and microscopic examination of the liver and kidney was carried out using standard methods while enzyme assay of the serum…